There seems to be a lot of misinformation floating around regarding Cetyl Myristoleate and trademarked formulations which contain Cetyl Myristoleate. There are many companies who claim to sell products that contain Cetyl Myristoleate, when in fact, they contain no Cetyl Myristoleate at al, but instead contain myristic acid (not the same as myristoleic acid), which has no known effect on the arthritic process. There are also products on the market which state that it is necessary to break down the Cetyl Myristoleate molecule for maximum assimilation into the body. Using a 9-chain triglyceride process, the molecule is broken down into small units, primarily the two original naturally occurring molecules: cetyl alcohol and myristoleic acid. The problem with this, according to Dr. Chuck Cochran, is that your body lacks the enzymes necessary to put the molecule back together again. It will not function as Cetyl Myristoleate in the liver. In other words, when it gets into the liver, it must be as Cetyl Myristoleate - not the broken down components of Cetyl Myristoleate, which is vital for it to be effective.
In Dr. Cochran's book At Last Collastin™ he states "I've researched all of them (suppliers of cetyl myristoleate products) quite extensively and have personally used several of them, and after having three of the best cetyl myristoleate products chemically analyzed by independent laboratories, Collastin™ with its unique formulation, is the best cetyl myristoleate product available today."
Further confusion regarding cetyl myristoleate is even evident in well known publications such as, SECOND OPINION, which is published monthly and is highly regarded among medical practioners and nearly 100,000 "informed readers," as you can see by the following article extracted from Vol. VI, No. 5 May 1996. In order to clear up the misunderstandings, we offer the information following this article. A correct understanding is vital BEFORE choosing a formulation such as Collastin™, or CMO™, for your own use, or that of your patients, clients, and friends.
An article about Cetyl myristoleate.
Extracted From SECOND OPINION Vol. V1, No 5 May 1996
Second Opinion is Published monthly, is highly regarded among medical practitioners and nearly 100,000 informed readers. (Although Second Opinion is highly regarded among medical practitioners, as you can see by the article, much misinformation regarding cetyl myristoleate and CMO™ are evident, which greatly contributes to the widespread confusion. CMO™ is NOT Cetyl Myristoleate. Please refer to information below about CMO™, Cetyl Myristoleate, and Collastin™.)
A New Miracle Cure for Arthritis
Every few years there is a new miracle cure for arthritis. There was DMSO; a miracle cure from the Bahamas; acupuncture; cod-liver oil; chelation therapy; and many more. Most of these treatments help, but none of them have proved to be a cure. The drug industry has also been turning out one miracle cure after another, aspirin, tylenol, Ibuprofen, and all the little profens etc. But all these companies have managed to do is produce more side effects than the more naturalist doctors.
But now we have a new star on the horizon that promises as much (or more) than the old sure cures. Again I'm skeptical, been through this so many times that I believe in the power of negative thinking, but it does indeed look promising. Harry Diehl, a 40-year-old employee of the U.S. Government, National Institute of Health reports: Four years ago I had arthritis so bad I could hardly walk and it was in my hands also. Diehl is 84 now and remarkably improved from treating himself with a compound I am still trying to learn to pronounce. It's called cerasomal cis 9 cetyl myristoleate. The trade name is CMO, so that's what we'll call it.
Diehl began testing CMO back in 1971 while still with the NIH and he continued to investigate it after he retired. The compound was isolated from Swiss albino mice and injected in laboratory rats. Then the (group of) rats injected with CMO and some rats who were not given CMO did not develop arthritis, but the unprotected ones all developed arthritis.
CMO is also found in male beavers and sperm whale oil. There is now an oral preparation that seems to work as well as the injections. It is absorbed by the mid-intestine and then migrates to the joints where it attaches itself and alters the immune response to the pain and swelling.....
When his rheumatologist told him he could no longer recommend cortisone to him, but only pain pills, Diehl went home, mixed a batch of CMO, and injected himself. His arthritis cleared quickly, as did his headaches and bronchitis. He thus made himself the first human guinea pig to be tested with CMO and just may make medical history. Yeah, here I go again; I'm really impressed with the reports I'm getting from my colleagues. This may be the cure we have been looking for. Even his doctor was so impressed with the results of his self treatment that he urged the Journal of Pharmaceutical Sciences to publish the report from Diehl, which they did.
(One) study involved 48 subjects of both sexes ranging from 29 to 82. The CMO was given orally with capsules being taken morning and night. Only two subjects failed to show marked improvement or complete relief of all the symptoms. The two patients who did not respond were both found to have severe liver disease. It is thought that liver damage from prolonged cortisone treatment for arthritis may block the healing effect of CMO. Most patients had a 70% to 100% return of joint mobility and a 70% to 100% reduction in pain. The initial response time is two to seven days and maximum response time is from 7 to 21 days. I don't own any part of the company and I have no claim on their sales, present and future, it's going to cost you to find out (if it works for you), but I think it's worth the investment. END OF EXTRACT FROM ARTICLE.
Cetyl Myristoleate is not CMO™, nor is it COLLASTIN™. Cetyl Myristoleate is the molecule that was developed by Harry W. Diehl, which started back in 1962 while he was working as a researcher and chemist at the National Institutes of Health in Bethesda, Maryland, assigned to the Institute of Arthritis, Metabolic, and Digestive Diseases.
CETYLMYRISTOLEATE, is a medium-chained fatty acid (oil) originally discovered when it was observed that a certain strain of white mice were totally arthritis resistant. Cety-myristoleate is a waxy substance at room temperature, but a clear, light yellow oily material at body temperature. It can be laid upon an absorbent bed of powder and the end product compressed into a tablet, or it can be encapsulated into a two-piece hard shell capsule, or a gelatin softshell capsule. Cetyl myristoleate is a simple, natural nutrient...not a drug. And Cetyl myristoleate doesn't cause any known side effects. Numerous, well-documented scientific studies have shown repeatedly the high efficacy of cety myristoleate in effectively treating patients afflicted with mild-to-severe cases of osteoarthritis, rheumatoid arthritis, and reactive psoriatic arthritis, and more recently, with many other auto-immune disorders. The results of these studies showed consistent, permanent relief from pain, inflammation, and marked deformation of nearly all interphalangeal & large joints.
In 1962 Harry set up a laboratory in his own home, and for over two years he spent his weekends and evenings working by himself. His experiments to find a cure for arthritis started with mice that proved to be immune to arthritis. What he was looking for was already in the common mouse. After two years of chemical sleuthing and laboratory experimenting, he finally isolated the molecule that gave these mice their immunity to arthritis - cetyl myristoleate.
His next step was to determine if a synthetic form was as effective as the cetyl myristoleate found in the mice. After creating the molecule from myristoleic acid and cetyl alcohol, he tested it on other laboratory animals. It proved to be just as effective.
The next thing he did, was to approach the pharmaceutical industry with his wonderful discovery, but he was in for a rude awakening. He assumed that any one of these drug companies would jump at the opportunity to finish his research and develop a cure for arthritis. This was not the case. Because his discovery occurs in nature, the product itself could not be patented, only its use. Without a product patent, a drug company would not be able to control who manufactures it and with no control of the market, the profits would have to be shared. None of the companies he presented it to would even consider it. Harry ended up taking his marvelous healing nutrient and putting it on the shelf until 1991, when he himself developed osteoarthritis in his hands, knees, and feet. After going to his medical doctor for help and eventually being told that there was nothing else that could be done for him, did Harry go back to his own discovery of cetyl myristoleate and made up a batch to try on himself. Within 30 days his arthritis pain was totally gone!
Even though Harry was a laboratory research scientist, his own experience motivated him to begin further studies. It was not until 1994 when he and a fellow chemist published his research in the Journal of Pharmaceutical Sciences that the health care industry became aware of it. Since cetyl myristoleate is an injectable oily substance that works best when it is injected at or near the site of the arthritic inflammation and has a very low bioavailability level in oral administration, it still took over two years to get to the point where material sources could be identified and processing methods developed to create a commercially-available product, hence, the trademarked formulations that contain Harry's cetyl myristoleate - CMO™ and COLLASTIN™ .
CMO™ is not cetyl myristoleate! Cerasomal cis-9-cetylmyristoleate is CMO™. CMO™ is a proprietary trademark that identifies this particular product. Cerasomal cis-9-cetylmyristoleate is just a name coined by Dr. L. Sands to sound unique and to distinguish his CMO™ product from other similar products. It is in no way the only true cetyl myristoleate product available on the market, nor is it the most effective, contrary to what CMO™ Distributors will tell you.
According to Dr. Chuck Cochran, Cerasomal cis-9-cetylmyristoleate, or CMO™ breaks the cetyl myristoleate down into a 9-chain triglyceride that the body lacks the proper enzymes to put back together, so that it reaches the liver as cetyl myristoleate. This is just one of the reasons why Dr. Cochran states that Collastin™ is much more effective, because it does reach the liver as cetyl myristoleate, which is critical. This might be one of the reasons why the instruction for using CMO™ states that additional supplements such as digestive enzymes can help and that they MUST contain lipase, amylase, and protease, but must not contain HCL (hydrochloric acid) or pancreatin, because these break down the CMO™ capsules too soon for proper absorption. The usage instructions also state that there are other supplements that will help the CMO™ be more effective such as, Bioflavanoids with Rutin, 1500mg -2000mg, Glucosamine Sulfate, Chondroitin Sulfate (and other cartilage products, because they assist in rebuilding worn cartilage in cases of osteo-arthritis, and Omega 3 supplements - fish oil or flaxseed oil.
In clinical tests CMO™ has been consistently 10-20% effective. CMO™ sells for $150.00 for 50 capsules that each contain 385mg of CMO™ (remember, CMO™ is not cetyl myristoleate).
COLLASTIN™ is not cetyl myristoleate, nor is it CMO™. Collastin™ is a proprietary formulation that was formulated by one of the world's largest encapsulators of pharmcopea grade nutritional products in the world. Collastin™ is a mixture of fatty acid esters. The principal fatty acid ester is cetyl myristoleate.
Fatty acids are the individual components or building blocks of lipids (fats) or oils in the same way that amino acids are the building blocks of proteins. If we take a fatty acid and add an alcohol molecule to it, we create an ester of that fatty acid. The ester, in this case, is called cetyl myristoleate. It's created by combining myristoleic acid, a fatty acid, with cetyl alcohol. If you take the cetyl myristoleate and combine it with a mixture of other fatty acid esters that work to complement each other, we create Collastin™ - the Rolls Royce of anti-aging products!
The exact mechanisms of Collastin's™ action are not fully understood. However, we can observe the results; and knowing the various etiologies or causes of certain diseases, we can make a hypothesis as to its mechanisms of action. First, Collastin™ functions as a surfactant, or super lubricant - a kind of WD-40 for the joints, as well as all of the other body tissues. A surfactant not only has a dissolving or thinning action, it also makes other nutrients easier to absorb. Because of Collastin's™ lubricating abilities, it makes the joints move more freely; it makes muscles glide more smoothly over other muscles, bursas, and bones; and at the same time, it softens these tissues making them more pliable. It also makes blood vessels more resilient, which allows them to expand and contract with the increase and decrease of blood volumes as the heart pumps. Hardening of the arteries, which contributes to heart disease - one of the major causes of death in our country - can also contribute to high blood pressure due to inelasticity of the arterial walls. Collastin™ not only lubricates the muscles, tendons, blood vessels, and joints, but every part of your entire body!
Secondly, it functions as an immune system modulator and possible stimulator. This is no doubt, on of the most exciting roles of Collastin™. As an immuno-modulator, it has been found to be effective in treating auto-immune disorders like rheumatoid arthritis and systematic lupus erythematosus. And last, it functions like omega-3 and omega-6 fatty acids in that it mediates inflammatory process. This last mechanism is probably the reason that we are seeing such far-reaching effects.
Cetyl myristoleate is presently being used to treat many inflammatory conditions, including Crohn's disease; irritable bowel syndrome; chronic bronchitis and emphysema; bursitis; tendonitis; rheumatoid and osteoarthritis; psoriasis and psoriatic arthritis; muscle tension headaches; and prostatitis. The one symptom common to most disease process at one state or another is inflammation. Inflammation is a normal response by the body to injury, and functions as part of the healing process. It becomes a problem, however, when it's uncontrolled and starts to produce more tissue damage.
To really understand how Collastin™ can work on so many different conditions, you need to know a little bit about prostaglandins and leukotrienes. Prostaglandins are a large group of biologically-active, unsaturated fatty acids that act almost like hormones, but unlike hormones their effects are local. In other words, they don't travel in the blood and effect organs or tissues in other parts of the body. They are modulators of the tissues in which they are formed. Prostaglandins are not only important in regulation of inflammation, pain, and swelling, they also help to regulate blood pressure, heart function, platelet aggregation (clotting factors), gastrointestinal function and activity, pancreatic hormone function, and nerve transmission. So, if we had something that regulated these prostaglandins, you could see how far-reaching such a product might be.
All these prostaglandins fall into three categories depending on how the carbon atoms are hooked together, specifically the number of double bonds. Series one and two come from the omega-6 fatty acids and series three comes from the omega-3 fatty acids. Series one and three prostaglandins are the favorable, or good prostaglandins; and prostaglandins in the second series are considered the unfavorable ones. For instance, prostaglandins of the second series cause increased inflammation, induce constriction of blood vessels, and promote platelet stickiness - factors that can increase the risk of heart disease and stroke. And as inflammation increases within damaged tissues, swelling and pain increase along with the chance of further damage by cutting off normal blood supply. In contrast, prostaglandins of the first and third series reduce inflammation, prevent the platelets from sticking together, and improve blood flow. By adding Collastin™ to your daily diet, you can manipulate prostaglandin metabolism, making sure that the good prostaglandins are in abundance and the bad prostaglandins are kept at a minimum. The big difference in Collastin™ - when compared to any other similar products - is the speed at which results are seen and the thoroughness of its activity. Patients who had been experiencing symptoms for years and had tried many, many different therapies, found total relief within a few days to a couple of weeks.
Leukotrienes are like prostaglandins in that they are chemical mediators of inflammation. Leukotrienes cause smooth muscle contraction in blood vessels and bronchial airways, and they also cause increased permeability in the blood vessels which results in edema or swelling of tissues. These substances also play an important role in asthma because of their ability to stimulate contraction of the smooth muscles that line the airways going into the lungs. Collastin™ may function as a leukotriene inhibitor. Many patients with airways that have been obstructed due to either inflammation or muscle contraction are now able to breathe better than they have in years!
One possible explanation of Collastin's™ ability to mediate an immune system that is attacking its own tissues and causing an auto-immune disease, is the inhibition of leukotriene B4 production. Leukotriene B4 is a compound that has potent chemotactic activity for certain phagocytic cells. These phagocytic cells normally ingest and destroy substances such as bacteria, protozoa, cells and cellular debris, but in auto-immune disorders they start to attack and ingest healthy tissues. In other words, Leukotriene B4 sends out a message to these phagocytic cells which affects their ability to differentiate the "good guys" from the "bad guys," telling them to "come here quickly." Suddenly, in one location, we have a whole bunch of Pac-Man-like activity eating up healthy tissues! Leukotrienes C4, D4, and E4, are responsible for producing many of the sympotms related to allergic reactions. Inhibiting leukotriene production may be one of the explanations for Collastins™ far-reaching results.
According to Dr. Cochran, "the amount of cetyl myristoleate is crucial to the success of the product." COLLASTIN™ is comprised of 40% Cetyl myristoleate, containing 12-14 grams of cetly myristoleate in a one month supply, added to other fatty acid esters, and making it the most potent form of cetyl myristoleate available. Our Saturation formula by itself is 60 - 70% effective, but when combined with our Maintenance Support formula, it is up to 88% effective!
Increasing effectiveness of Collastin™
As fantastic as Collastin™ is, its effectiveness can be improved by another 10 to 20 percent by adding a few additional natural ingredients, which can be found in our Maintenance Support formulation.
In nature, we observe that nothing works or stands alone. Collastin™ itself has a group of fatty acid esters working with the cetyl myristoleate to increase its effectiveness. There always seems to be a collaboration, or supporting complementary action, which makes things happen. This synergistic interation produces a total effect that is greater than the sum of the individual effects.
Next to Collastin™, glucosamine has relieved the symptoms of osteoarthritis than any other one nutrient. Glucosamine is manufactured by the body and is primarily to help form the cushioning components of joint fluids and surounding tissues. It thickens synovial fluid, making it more elastic; repairs the cartilage in damaged arthritic joints; and creates more support for joints, including the vertebrae. Besides helping to form the cartilage, tendons, ligaments, and snyovial fluid in the joint, it also plays a role in the formation of nails, skin, eyes, bones, and heart valves. And, finally, it's involved in the mucous secretions of the digestive, respiratory, and urinary tracts.
As we age, we lose the ability to manufacture glucosamine, which results in degeneration of the structures within the joints. Since we don't get a significant amount in our diets, we need to supplement with some form of glucosamine. Available sources of glucosamine are derived from chitin, the exoskeleton of shrimp, lobsters, and crabs. Presently, it's commercially sold in three forms: 1) glucosamine sulfate (GS); 2) N-acetyl-glucosamine (NAG); 3) glucosamine hydrochloride (GHCL). The N-acetyl-glucosamine has been found to be not as effective in treating joint conditions, and actually very little, if any, ends up in the joints. After reading the research comparing glucosamine sulfate to the glucosamine hydrochloride, Dr. Cochran started recommending the hydrochloride form, because it's found to be just as effective, and it's less expensive.
There will be many health care providers who claim that sulfate form of glucosamine is more effective than the hydrochloride form, but the information found by Dr. Cochran are pretty convincing. First of all, most of the studies done from 1980 to 1994 were with the sulfate form because it was made available by the Italian pharmaceutical company which had a proprietary position or patent on the sulfate. So, it was to their advantage to make the sulfate form available for clinical studies. However, in studies performed as early as 1971, comparing the effects of glucosamine sulfate, glucosamine iodide, and glucosamine hydrochloride, it was found that glucosamine hydrochloride had the strongest effect.
The reason for its stronger effect is that it's much more pure. Actually, glucosamine sulfate is made from glucosamine hydrochloride by adding either sodium or potassium sulfate. Adding these additional compounds increases the cost by another 50percent. All of the glucosamine sulfate imported into the United States is only 80 percent pure, with the remaining 20 percent being sodium or potassium chloride. This is done because the glucosamine sulfate is very unstable and tends to decompose, turn brown, and lose its effectiveness. Glucosamine hydrochloride, on the other hand, is very stable and is 99 percent pure. In this unmixed form, it delivers 83 percent of the glucosamine to the joints. Glucosamine sulfate mixed with other salts distributes only 62 percent of the glucosamine to the joints. Put another way, you would have to take 1995 milligrams of glucosamine sulfate to equal the effects of 1500 milligrams of glucosamine hydrochloride! This decreases your cost even further.
You may also hear that the sulfer in the glucosamine sulfate is necessary for the construction of the cartilage matrix. The original researchers of glucosamine sulfate found, however, that the results obtained in treating osteoarthritis were due to the glucosamine and not to the sulfate. They discovered that the sulfate, chloride, and iodide salts are passed from the body as waste. And the sulfer used to construct these joint structures actually comes from existing proteins present in the cartilage.
Sulfer is, however, critical in reconstructing connective and joint tissue and can be increased by consuming more sulfer-containing foods including garlic, onions, eggs, and asparagus, or by taking a supplement like MSM.
Another interesting point to consider is what really happens during the digestion of glucosamine sulfate. Your stomach contains hydrochloric acid which is necessary for the digestion of food. When the glucosamine sulfate enters the stomach, the sulfate portion is split off and the hydrochloride is attached to the glucosamine creating glucosamine hydrochloride! The sulfate molecule is essentially lost due to its very low concentrations, compared to the large amount of hydrochloric acid present in you stomach. If your body is going to turn it into glucosamine hydrochloride, why not take it in that form in the first place and eliminate all the unnecessary salt that you probably don't need anyway.
The adult body contains about 10 to 20 milligrams of manganese. Most of this is concentrated in the pancreas, bone, liver, and kidneys. It functions as a helper in many enzyme processes in the body, including the enzyme glycosyltransferase that's responsible for the production of the glycosaminoglycans (GAGs). Glycosaminoglycans are protein/carbohydrate complexes that attract and bind water to the cartilage matrix making the cartilage surface bery slick or slippery. Manganese is also needed to create components of the synovial fluid (fluid found within the joint that acts as a lubricant), which gives it the thick viscous quality.
A deficiency of manganese in the body could result in a decrease in the slippery qality of the cartilage surface, as well as a decrease in the fluid found with the joint. This would eventually cause the joint to dry out. As the cartilage starts to dry out, it loses its shock absorbing ability and with time can even start to break into small pieces. These small pieces of broken cartilage within the joint can cause a lot of pain when they lodge themselves next to sensitive tissues. If you've ever rubbed a wet ice cube over another wet ice cube, you would have a little insight as to how slick healthy cartilage is supposed to be. Dried out and damaged cartilage is similar to rubbing sandpaper over a piece of rough wood.
Manganese is also a component of the antioxidant enzyme superoxide dismutase, or SOD. SOD protects the body's cells from free radical damage and inflammation. In Europe, this enzyme is used in an injectable form to treat many inflammatory conditions, including rheumatoid arthritis. Although oral SOD is available in the United States, some studies indicate that it's very poorly absorbed. However, by using manganese supplementation, SOD tissue levels are increased, thereby, increasing the therapeutic effects of this super antioxidant.
Esterified Vitamin C
Vitamin C functions in over 300 different physiological processes in the body. We, as humans, are one of the few animals that do not produce our own vitamin C. A 60-pound dog, for instance, produces about four grams (or four thousand milligrams) per day. Vitamin C has been found to reduce cancer rates; boost the immune system; function as an antioxidant; protect against pollutants; and enhance the healing of wounds. It primarily functions as an essential co-factor in the manufacturing of collagen. Collagen is a protein complex that functions as the cement that holds our teeth, bones, skin, and tissues together. One half of all the total protein in the body is collagen.
Esterified vitamin C, also known as Ester-C®, is a special form of vitamin C that is not acidic, gentle on the digestive system, and increases vitamin C (ascorbic acid) transport into the cells. Ester-C® contains a metabolite of ascorbic acid, threonic acid, that causes ascorbic acid to be transported through the cell membranes more easily, thus, increasing intracellular levels. It's simple - Ester-C® is easier to digest and absorb, and it gets more vitamin C inside the cells.
Boswellin is the registered trademark for a scientifically standardized Boswellia serrata extract. Boswellia is indigenous to various parts of Africa with the species Boswellia serrata unique to India. Multiple studies have indicated that this plant has many positive effects on the body, without any negative side effects. After studying all of the clinical and laboratory studies available, once again, Nature truly does provide an answer for every disease known to man. Nature addreses the causes of disease without producing toxins in the body and creating dangerous side effects.
Boswellin™ is remarkable. It has some similarities to Collastin™, in that it inhibits leukotriene production and, consequently, decreases inflammation throughout the body. By inhibiting this inflammatory response, the chipping away of the cartilage within the joint is reduced and the repair process can take place.
In a human study performed in 1987 on 175 subjects, Boswellin™ performed remarkably well! These patients - ages 10 to 50 years old - had been diagnosed with rheumatoid arthritis and ankylosing spondylitis, a spinal arthritic condition in which the vertebrae eventually fuse together. Clinical evaluations were performed on a regular basis over a six-year period. The severity of pain, morning stiffness, joint scores, disability scores, and grip strength were evaluated. Sixty-weven percent of the subjects showed good to excellent results; 30 percent had fair results; and only three percent failed to show any improvement.
In another human, double-blind, placebo study, Boswellin™ was found to significantly reduce the erythrocyte sedimentation rate (ESR) after only four weeks of daily use. ESR is a blood test that measures the speed at which red blood cells settle to the bottom of a glass tube, and is used as a screening test for tissue inflammation. A placebo was then used instead of the Boswellin™, and the ESRs were checked again four weeks later. They increased an average of 20 percent, showing that inflammation increased during placebo use.
Besides being an excellent anti-inflammatory and anti-arthritic, Boswellin has also been used in liver detoxification; to decrease fats circulation in the bloodstream; and as a treatment for atherosclerosis and gastrointestinal ulcers. Boswellin™ has also been found to inhibit tumor growth in laboratory animals. In on particular study, tumors were reduced by 84 percent after being treated with Boswellin™. And when the dose of Boswellin™ was tripled, tumors were reduced by 96 percent!
Sea cucumbers - also known as the vegetable of the sea, or cucumaria - are abundant in ocean tidal zones throughout the world and have been part of man's diet for thousands of years. Sea cucmbers contain special compounds that help modulate the balance of prostaglandins, which regulate inflammatory processes.
An August 1992 study, conducted by researchers at the University of Queenland, showed that the sea cucmber not only functioned as an anti-inflammatory, but it also provided the necessary nutrients to help rebuild damaged tissue in arthritic joints. The special substances, known as mucopolysaccharides and chondronitins, are often lacking in individuals with arthritis and connective tissue diseases. Sea cucumbers are also a source of vitamins A, B1 (thiamin), B2 (riboflavin), B3 (niacin), and C, as well as the minerals calcium, iron, magnesium, and zinc.
Dr. Mitchell Kurk, Medical Director of the Biomedical Revitalization Center of Lawrence, New York, found that sea cucumber improved symptoms of his arthritic patients by 70 percent. And in Australia and New Zealand, sea cucumber has been approved by the Department of Health as an effective arthritis treatment.
A component of over 200 enzymes in our bodies, zinc functions in more enzymatic reactions than any other trace mineral. Zinc is necessary for normal cell division and is critical for the synthesis of DNA, RNA, and protein. It's also necessary for the proper action of many of the body's hormones, including insulin, growth hormone, thymic hormones, and the sex hormones. Most importantly, zinc is required for skin and connective tissue production through its affects on collagen and glycosaminoglycans.
Although severe zinc deficiencies are rare, marginal deficiencies are very common - especially among the elderly. This is, most likely, due to a decreased pancreatic function, resulting from the zinc in the diet not being absorbed. Although zinc is found in many plant foods, most of it is not bioavailable. In plants, zinc binds to a fiber compound called phytic acid to form zinc-phytate, which is not absorbed by the body. The best food source of zinc is oysters, but it's also found in high concentrations in other shellfish, fish and red meats.
Zinc In Rheumatoid Arthritis
Zinc levels in those with rheumatoid arthritis are typically low; and in several studies zinc was found to reduce joint swelling, joint tenderness, and morning stiffness. Part of the reason for its effectiveness may be that zinc has antioxidant effects and functions in th antioxidant enzyme superoxide dismutase, or SOD.
Zinc In Collagen Synthesis and Wound Healing
Zinc is required for making protein and the growth of cells and, therefore, it's necessary for the repair of damaged tissues. Zinc supplementaiton has been shown to decrease the normal time it takes for wounds to heal, while zinc deficiency leads to a longer period of time to heal. These effects appear to be due to zinc's special promotional role in skin and connective tissue metabolism.
White spots on your fingernails can sometimes be used to determine the body's zinc levels. Decreased zinc levels prolong the normal time it takes for wounds to heal; and after nail bed injuries, these lesions can appear under you fingernails.
Zinc and Immunity
Adequate zinc levels in the tissues are necessary for proper function of the immune system. Zinc deficiency results in an increased susceptibility to infection. When zinc levels are low, the number of T-cells (lymphocytes from the thymus gland) decrease; hormones produced in the thymus gland decrease; and many white blood cell functions necessary for the immune response are compromised.
As well as stimulation of the immune system, zinc has displayed virus-inhebiting activity. In one double-blind clinical study, zinc supplementation significantly reduced the average duration of colds by seven days.
Zinc and the Prostrate Gland
Zinc concentrations in the prostate glands of men are normally very high. Zinc deficiencies can be a contributing factor in the high rate of benign prostatic hypertrophy or enlargement of the prostate gland. It's estimated that 50 to 60 percent of men between the ages of 40 and 59 years of age have prostatic enlargement. And zinc supplementation has been shown to reduce the size of the prostate and symptomatology in the majority of these cases.
Zinc is also critical to male sexual function. It's used in every aspect of male reproduction, including hormone meabolism; the creation of sperm and sperm motility; as well as testosterone production. Zinc levels are much lower in infertile men with low sperm counts, which indicates that zinc is a contributing factor in infertility.
It is ALWAYS highly recommended to supplement your diet with digestive enzymes! This cannot be stressed enough. You need to gain a thorough understanding of the digestive process that takes place in the stomach once food has been ingested. Many of the conditions we see today are directly related to the body's inability to completely digest food. Undigested food particles end up in the blood stream in an unusable form. The body sees these food particles as foreign invaders and kicks in with the immune response, which happens every time food is eaten! The condition is called deigestive leukocytosis and can be diagnosed by evaluating the number of white blood cells in the blood, before and after one eats. No wonder many people have immune systems that are extremely overworked and very tired.
Without Enzymes There Is NO LIFE!
Enzymes are fundamental to all living processes in the body, necessary for every chemical reaction and the normal activity of our organs, tissues, fluids, and cells. There are hundreds of thousands of these"workers of Nature."
All the vitamins, minerals, and hormones we rely on, need enzymes to work. Enzymes move our muscles, stimulate our nerves, make our heart beat, and keep us breathing. Enzymes are specialized living proteins that enable your body to digest and assimilate proteins, carbohydrates, fats, and plant fibers.
There are three classes of enzymes. These include plant or food enzymes, found in all raw foods; digestive enzymes, which are secreted by the pancreas; and metabolic enzymes, produced in the cells to run all body processes. However, "only plant enzymes initiate digestion in the stomach, which is why when you take plant enzymes it spares the pancreas from doing all of your digestion." Unlike conventional drugs that control body chemistry, plant enzymes enhance nourishment, so that the body can control itself. (Dr. Lita Lee, Ph.D.)
Since food cooked over 118 degrees has no living food enzymes, we force our body to supply digestive enzymes, which causes a temporary deficit in metabolic enzymes, since our body cannot produce both at the same time. This may mean our body may be unable to repair organs and fight disease when necessary. If each of us would take in more enzymes from an outside source, our enzyme reserve would not be depleted at such a rapid pace. This would keep our metabolic enzymes more evenly distributed throughout the body. This is one of the most important health-promoting measures than YOU can implement into your life!
You can expect a substantial increase in absorption and digestion of cooked foods when supplementing your diet with digestive enzymes. Benefits include reducing constipation and the time toxic materials are held within the body through better elimination. Digestive enzymes can help strengthen the immune system. Many doctors, researchers, and scientists now believe that plant source enzymes may be a key factor in prolonging your life!
If your system is lacking enzymes -- substances basic to all life processes -- it may be why your chronic condition doesn't improve.
The following are some of the conditions commonly associated with a deficiency of each one of the basic enzymes:
NOTE: Our Maintenance Support Formulation includes all of the above nutrients except Digestive enzymes , however, we do offer one of the best and most complete formulations on the market today that also includes "friendly" bacteria.
NOTE: Much of the above information regarding Collastin™ and the additional beneficial nutrients can be found in Dr. Cochran's book At Last Collastin™
There have been two clinical studies completed recently. One of them involved 431 patients with various forms of arthritis. The results were remarkable.Very significant improvement was observed in 64 percent of the individuals using the fatty acid esters found in COLLASTIN™; and 87 percent showed improvement by combining these esters with other important nurtients that are mentioned above.
In another study comprised of 48 patients with osteoarthitis, rheumatoid arthritis, and reactive psoriatic arthritis, only two of these individuals failed to respond. These two were found to have liver disease, one from alchol abuse ant the other from extensive steroid use. Liver disfunction has been shown to interfere with the action of Collastin™ and reduce its effectiveness. In his research, Harry Diehl found that the liver acts as a storage center for cetyl myristoleate, and adequate liver function appears to be necessary for effectiveness.
In group #1, eleven subjects presenting with mild to moderately severe osteoarthritis and one with reactive psoriatic arthritis were supplied with 16 capsules, two 75mg capsules to be taken each morning and evening for four days. Nine reported about 20% to 30% improvement in articulation and inflammation and about 40% to 50% relief of arthritic pain in 36 hours. In these nine subjects, improvement continued rapidly for the next 60 hours, reaching a 70% to 80% overall improvement by the end of the four days. Two of the three latter subjects continued to improve over the following week despite the fact that they were no longer taking the capsules. However, about half of this group experienced the return of some mild arthritic symptoms after about three to five weeks. (Although not included as part of this study, all subjects in this group were treated again and their symptoms have not returned). The patient with reactive psoriatic arthritis also experienced an almost complete reversal of his associated very severe psoriatic skin condition affecting about 20% of his total skin.
In group #2, nine subjects presenting with severe to crippling rheumatoid arthritis were supplied with 50 capsules to be taken in 2 series, two 75mg capsules each morning and evening for seven days, with a seven-day interval before repeating the same dosage for 5 ½ more days. Four of these subjects were unable to walk and were accustomed to being transported by wheelchairs. One, her femur being fused at the hip, was unable to achieve a sitting position for wheelchair transport. She could, however, move about slowly on crutches as long as she was accompanied by someone to aid her maintaining her balance. Otherwise she could only stand or lie down. The remaining four could move about with canes or walkers. All nine subjects presented with pain, inflammation, and large joints. Five presented with limited lumbar flexion and pain in the vertical column. All had difficulty grasping and manipulating common objects.
Within three days of treatment, six subjects in the group reported a 30% to 50% decrease in pain and 20% to 30% increase in joint mobility, and three subjects reported little change. Within seven days, five subjects reported a 70% to 90% decrease in pain and a 70% to 80% increase in joint mobility. Three subjects reported to be totally free of pain with almost complete return of joint mobility and marked improvement in joint deformation. One patient reported no perceptible change.
On the fourteenth day, at the end of the one week interval without treatment, six subjects reported minor continuing improvement; two reported maintaining their improved status, and one continued to show no improvement. Treatment was resumed on the fifteenth day for 5 ½ more days.
By the end of the treatment period all but two subjects reported to be 90% free of pain with return of 70% to 100% mobility. The fused hip joint remained fused, but with the return of over 70% mobility in the other joints the subject felt hip surgery now to be worth consideration. The one non-responsive subject proved to have cirrhosis of the liver, which may have been the reason of her inability to respond to treatment. Further investigation is necessary to determine the role of liver function in this Protocol.
In group# 3, fourteen subjects presenting with mild to moderately severe rheumatoid arthritis were supplied with 24 capsules, two 75mg capsules to be taken each morning and evening for six days. After three days of treatment, eleven reported about 20% to 30% improvement in articulation and inflammation, and about 40% to 50% relief of arthritic pain. In these eleven subjects improvement continued rapidly over the next four days, approaching the 80% to 100% level. The remaining three subjects reported similar improvements by the end of the fourth day, with an overall improvement of 70% to 80% after seven days.
Most of the subjects continued to report minor additional improvement for one week or more even though they were no longer under treatment. However, six in this group began to experience the return of some mild arthritic symptoms after about three to four weeks. (Although not included in this study, all of the subjects in this group were treated again and their level of improvement has subsequently stabilized).
In group#4, fourteen subjects presenting with severe to crippling osteoarthritis were supplied with 50 capsules to be taken in two series, two 75mg capsules each morning and evening for seven days, with a seven-day interval before repeating the same dosage for 5 ½ more days. Three of these subjects were unable to walk and were accustomed to being transported by wheelchairs. The other eleven could move about with crutches, walkers, or canes. All presented with pain, inflammation, and marked deformation of nearly all interphalangeal and large joints. Four presented with limited lumbar flexion and pain in the vertical column. Ten had difficulty grasping and manipulating common objects.
After four days of treatment, ten in this group reported 30% to 50% improvement in articulation and inflammation and about 40% to 60% relief of arthritic pain. In these ten subjects improvement continued rapidly over the next three days, reaching 80% to 100% by the end of seven days. One reported no perceptible change.
On the fourteenth day, at the end of the one week interval without treatment, four reported maintaining their improved status, and one continued to show no improvement. Treatment was resumed on the fifteenth day for 5 ½ more days.
By the end of the treatment period, eleven subjects reported 80% to 100% relief of pain with a return of 80% to 100% mobility. Two subjects reported 70% to 80% return of articular mobility with a 70% to 90% reduction in arthritic pain. The one non-responsive subject proved to have previous liver damage as a result of sports related steroid abuse. Further studies are necessary to determine the role of liver function in this Protocol.
The results of this study lead to several conclusions regarding its five principal objectives:
Optimum dosage levels appear to be equal for all three types of arthritis investigated:
osteoarthritis, rheumatoid arthritis, and reactive psoriatic arthritis. This evidence by the gradual return of minor arthritis symptoms in several of those treated with only 16 or 24 capsules and no regression in those treated with 50 capsules in two series separated by one week without treatment.
Dosage level requirements appear to be equal irrespective of the severity of the subject's condition. Initial response time for minor improvement appears to vary from two to seven days irrespective of the severity of the subject's condition.
The time for maximum attainable response appears to vary from seven to twenty-one days, resulting in 70% to 100% overall improvement. (Apart from this study, three of the most severely afflicted subjects were treated again after a five-week interval, resulting in an additional 10% to 20% overall improvement.)
The two non-responding subjects both proved to have suffered previous damage to the liver from steroid or alcohol abuse, indicating that impaired liver function may preclude success with this Protocol.
Diehl, H. and May, E.L., Cetyl Myristoleate Isolated from Swiss Albino Mice: An Apparent Protective Agent Against Adjuvant Arthritis in Rats, Journal of Pharmaceutical Science, Vol. 83, March 1994.
United States Patent #4049824, September 20, 1977, Cetyl Myristoleate.
NutriPlus '97 SDI Systems, Inc., Dallas, Texas
CMO™: CMO™ is a copyrighted name of Cerasomal-Cis-9-Cetyl Myristoleate, which this manufacturer claims is an analog of Cetyl Myristoleate.
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